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[The influences of human apolipoprotein E mutants on the learning and memory of cerebral cortex in transgenic mice].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Aug 2000

Liao Z, Qi Z, Sun M, Yang D, Yun J

Abstract excerpt

OBJECTIVE: To study the influences of the mutants of human apolipoprotein E on the function of cerebral cortex. METHODS: The Southern blot hybridization and ELISA techniques were used for identification of integration and expression of human apoE4 and apoE7 genes at the mice chromosome and in the serum of F1 transgenic mice. Then the active avoidance response test was performed to determine the alteration of...

Topics

Animals
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Cerebral Cortex
Cholesterol
Humans
Learning
Memory
Mice
Mice, Transgenic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Triglycerides

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PMID: 12903448

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