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Article

Persistence without pathology in phosphoglycan-deficient Leishmania major.

Science (New York, N.Y.) - 29 Aug 2003

Späth Gerald F, Lye Lon-Fey, Segawa Hiroaki, Sacks David L, Turco Salvatore J, Beverley Stephen M

Abstract excerpt

Leishmania infections involve an acute phase of replication within macrophages, typically associated with pathology. After recovery parasites persist for long periods, which can lead to severe disease upon reactivation. Unlike the role of host factors, parasite factors affecting persistence are p...

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Identifiers

PMID: 12947201
DOI: 10.1126/science.1087499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12947201-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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