Article
A mutant heterodimeric myosin with one inactive head generates maximal displacement.
The Journal of cell biology - 4 Aug 2003
Kad Neil M, Rovner Arthur S, Fagnant Patricia M, Joel Peteranne B, Kennedy Guy G, Patlak Joseph B, Warshaw David M, Trybus Kathleen M
Abstract excerpt
Each of the heads of the motor protein myosin II is capable of supporting motion. A previous report showed that double-headed myosin generates twice the displacement of single-headed myosin (Tyska, M.J., D.E. Dupuis, W.H. Guilford, J.B. Patlak, G.S. Waller, K.M. Trybus, D.M. Warshaw, and S. Lowey. 1999. Proc. Natl. Acad. Sci. USA. 96:4402-4407). To determine the role of the second head, we expressed a smooth...
Topics
- Actins
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Animals
- Binding Sites
- Cell Line
- Cell Movement
- Dimerization
- Eukaryotic Cells
- Mutation
- Myosins
- Protein Structure, Tertiary