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Article

Investigating the interfacial binding of bacterial phosphatidylinositol-specific phospholipase C.

Biochemistry - 12 Aug 2003

Wehbi Hania, Feng Jianwen, Kolbeck James, Ananthanarayanan Bharath, Cho Wonhwa, Roberts Mary F

Abstract excerpt

The interactions of PI-PLC with nonsubstrate zwitterionic [phosphatidylcholine (PC)] and anionic [phosphatidylmethanol (PMe), phosphatidylserine, phosphatidylglycerol, and phosphatidic acid] interfaces that affect the catalytic activity of PI-PLC have been examined. PI-PLC binding is strongly coupled to vesicle curvature and is tighter at acidic pH for all of the phospholipids examined. PI-PLC binds to small...

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Source

Identifiers

PMID: 12899624
DOI: 10.1021/bi034195+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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