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Article

Cation-π interactions as lipid-specific anchors for phosphatidylinositol-specific phospholipase C.

Journal of the American Chemical Society - 17 Apr 2013

Grauffel Cédric, Yang Boqian, He Tao, Roberts Mary F, Gershenson Anne, Reuter Nathalie

Abstract excerpt

Amphitropic proteins, such as the virulence factor phosphatidylinositol-specific phospholipase C (PI-PLC) from Bacillus thuringiensis , often depend on lipid-specific recognition of target membranes. However, the recognition mechanisms for zwitterionic lipids, such as phosphatidylcholine, which is enriched in the outer leaflet of eukaryotic cells, are not well understood. A 500 ns long molecular dynamics...

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Source

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Identifiers

PMID: 23506313
DOI: 10.1021/ja312656v
PMCID: PMC3797534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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