Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel mechanism of drug resistance in kala azar field isolates.

The Journal of infectious diseases - 15 Aug 2003

Singh Neeloo, Singh Ramsing Th, Sundar Shyam

Abstract excerpt

Clinical resistance to pentavalent antimonial drugs in the form of sodium antimony gluconate (SAG) has become a major problem in the treatment of kala azar (visceral leishmaniasis) in India. The mechanism of resistance is unclear in these clinical isolates, although work has been conducted with Leishmania species mutants selected in vitro by stepwise increase of drug concentration, using antimony-related metal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiprotozoal Agents
Share to Base Sequence
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Protozoan

Share to Leishmania donovani

Share to Leishmaniasis, Visceral

Share to Molecular Sequence Data

Share to Open Reading Frames

Source

Identifiers

PMID: 12898450
DOI: 10.1086/377133

Genes

SAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel mechanism of drug resistance in kala azar field isolates.PMID 12898450Read ↗

Differential gene expression analysis in antimony-unresponsive Indian kala azar (visceral leishmaniasis) clinical isolates by DNA microarraySemantic proximity Read ↗

Antimony resistance mechanism in genetically different clinical isolates of Indian Kala-azar patientsSemantic proximity Read ↗

The overexpression of genes of thiol metabolism contribute to drug resistance in clinical isolates of visceral leishmaniasis (kala azar) in India.Semantic proximity Read ↗

Mutations in an Aquaglyceroporin as a Proven Marker of Antimony Clinical Resistance in the Parasite Leishmania donovani.Semantic proximity Read ↗

Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from IndiaSemantic proximity Read ↗

Role of Aquaglyceroporin (AQP1) Gene and Drug Uptake in Antimony-resistant Clinical Isolates of Leishmania donovaniSemantic proximity Read ↗

Epidemiological Insights: Unraveling Drug Resistance in Leishmania Species through Comprehensive StudiesSemantic proximity Read ↗

Genetic typing reveals monomorphism between antimony sensitive and resistant Leishmania donovani isolates from visceral leishmaniasis or post kala-azar dermal leishmaniasis cases in India.Semantic proximity Read ↗

Miltefosine Resistant Field Isolate From Indian Kala-Azar Patient Shows Similar Phenotype in Experimental Infection.Semantic proximity Read ↗

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.Semantic proximity Read ↗

Leishmania spp. genetic factors associated with cutaneous leishmaniasis antimony pentavalent drug resistance: a systematic review.Semantic proximity Read ↗

Role of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovani.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.