Article
Polygenic and directional regulatory evolution across pathways in Saccharomyces.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010
Bullard James H, Mostovoy Yulia, Dudoit Sandrine, Brem Rachel B
Abstract excerpt
The search to understand how genomes innovate in response to selection dominates the field of evolutionary biology. Powerful molecular evolution approaches have been developed to test individual loci for signatures of selection. In many cases, however, an organism's response to changes in selective pressure may be mediated by multiple genes, whose products function together in a cellular process or pathway. Here...
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