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Article

Alternative splicing controls myotonic dystrophy protein kinase structure, enzymatic activity, and subcellular localization.

Molecular and cellular biology - 1 Aug 2003

Wansink Derick G, van Herpen René E M A, Coerwinkel-Driessen Marga M, Groenen Patricia J T A, Hemmings Brian A, Wieringa Bé

Abstract excerpt

Transcripts of the myotonic dystrophy protein kinase (DMPK) gene, a member of the Rho kinase family, are subject to cell-type specific alternative splicing. An imbalance in the splice isoform profile of DMPK may play a role in the pathogenesis of DM1, a severe multisystemic disorder. Here, we report how structural subdomains determine biochemical properties and subcellular distribution of DMPK isoforms. A newly...

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Identifiers

PMID: 12897125
DOI: 10.1128/MCB.23.16.5489-5501.2003
PMCID: PMC166319

Genes

DMPK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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