Article
Coiled-coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms.
The FEBS journal - 1 Mar 2006
van Herpen René E M A, Tjeertes Jorrit V, Mulders Susan A M, Oude Ophuis Ralph J A, Wieringa Bé, Wansink Derick G
Abstract excerpt
The myotonic dystrophy protein kinase polypeptide repertoire in mice and humans consists of six different splice isoforms that vary in the nature of their C-terminal tails and in the presence or absence of an internal Val-Ser-Gly-Gly-Gly motif. Here, we demonstrate that myotonic dystrophy protein kinase isoforms exist in high-molecular-weight complexes controlled by homo- and heteromultimerization. This...
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