Article
Amyotrophic lateral sclerosis, lead, and genetic susceptibility: polymorphisms in the delta-aminolevulinic acid dehydratase and vitamin D receptor genes.
Environmental health perspectives - 1 Aug 2003
Kamel Freya, Umbach David M, Lehman Teresa A, Park Lawrence P, Munsat Theodore L, Shefner Jeremy M, Sandler Dale P, Hu Howard, Taylor Jack A
Abstract excerpt
Previous studies have suggested that lead exposure may be associated with increased risk of amyotrophic lateral sclerosis (ALS). Polymorphisms in the genes for delta-aminolevulinic acid dehydratase (ALAD) and the vitamin D receptor (VDR) may affect susceptibility to lead exposure. We used data from a case-control study conducted in New England from 1993 to 1996 to evaluate the relationship of ALS to polymorphisms...
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