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The analysis of BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives.

Human mutation - 1 Jul 2003

Hu Zhen, Wu Jiong, Liu Can-Hui, Lu Jing-Song, Luo Jian-Ming, Han Qi-Xia, Shen Zhen-Zhou, Shao Zhi-Ming

Abstract excerpt

To study the BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives, 41 patients' genomic DNA from peripheral mononuclear blood cells was studied by using single strand conformational polymorphism (SSCP) and DNA sequencing. The BRCA1 mutations were detected in the whole gene sequence. Three novel disease-causing mutations (c.582C>T, c.735C>T and c.2790delT) occurred in...

Topics

Adult
Age of Onset
BRCA1 Protein
Breast Neoplasms
China
DNA Mutational Analysis
DNA, Neoplasm
Female
Genes, BRCA1
Humans
Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 12815604
DOI: 10.1002/humu.9156

Genes

BRCA1

Variants

Provenance

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