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Article

SIR1, an upstream component in auxin signaling identified by chemical genetics.

Science (New York, N.Y.) - 22 Aug 2003

Zhao Yunde, Dai Xinhua, Blackwell Helen E, Schreiber Stuart L, Chory Joanne

Abstract excerpt

Auxin is a plant hormone that regulates many aspects of plant growth and development. We used a chemical genetics approach to identify SIR1, a regulator of many auxin-inducible genes. The sir1 mutant was resistant to sirtinol, a small molecule that activates many auxin-inducible genes and promotes auxin-related developmental phenotypes. SIR1 is predicted to encode a protein composed of a ubiquitin-activating...

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Identifiers

PMID: 12893885
DOI: 10.1126/science.1084161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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