Article
Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins.
Biochemical and biophysical research communications - 1 Aug 2003
Azuma Mitsuyoshi, Tamada Yoshiyuki, Kanaami Sayaka, Nakajima Emi, Nakamura Yoshikuni, Fukiage Chiho, Forsberg Neil E, Duncan Melinda K, Shearer Thomas R
Abstract excerpt
The purpose of the present study was to compare the susceptibility of crystallins proteolyzed by ubiquitous calpain 2 and by lens-specific calpain Lp82 to insolubilization. To test this, transgenic (TG) mice expressing a calpain 2, in which the active site cysteine 105 was mutated to alanine, wer...
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