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Article

Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase.

The Journal of biological chemistry - 28 Mar 2014

Santhoshkumar Puttur, Xie Leike, Raju Murugesan, Reneker Lixing, Sharma K Krishna

Abstract excerpt

The accumulation of crystallin fragments in vivo and their subsequent interaction with crystallins are responsible, in part, for protein aggregation in cataracts. Transgenic mice overexpressing acylpeptide hydrolase (APH) specifically in the lens were prepared to test the role of protease in the generation and accumulation of peptides. Cataract development was seen at various postnatal days in the majority of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24554718
DOI: 10.1074/jbc.M113.510677
PMCID: PMC3979366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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