Article
Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study.
Human heredity - 1 Jan 2003
Stram Daniel O, Haiman Christopher A, Hirschhorn Joel N, Altshuler David, Kolonel Laurence N, Henderson Brian E, Pike Malcolm C
Abstract excerpt
We describe an approach for picking haplotype-tagging single nucleotide polymorphisms (htSNPs) that is presently being taken in two large nested case-control studies within a multiethnic cohort (MEC), which are engaged in a search for associations between risk of prostate and breast cancer and co...
Topics
- Aromatase
- Breast Neoplasms
- Case-Control Studies
- Cohort Studies
- Computer Simulation
- Female
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Male
- Polymorphism, Single Nucleotide
- Prostatic Neoplasms