Article
[Evaluation of different methods in monitoring YMDD motif mutations associated with lamivudine resistance].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Jul 2003
Hu Ying-ying, Jiang Jia-ji, Li Dian, Lin Cai-wen, Li Qin-guang, Chen Yi
Abstract excerpt
OBJECTIVES: To evaluate the three different methods in monitoring the lamivudine-resistant HBV mutants in lamivudine-treated patients with chronic hepatitis B. METHODS: The sensitivity and specialty of melting curve assay and polymerase chain reaction microplate nucleotide hybridization-enzyme linked immunosorbent assay (PCRmnh-ELISA) were compared with those of mismatch polymerase chain reaction-restriction...
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