Article
In silico prediction and validation of the importance of the Entner-Doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Escherichia coli.
Biotechnology and bioengineering - 30 Sept 2003
Hong Soon Ho, Park Si Jae, Moon Soo Yun, Park Jong Pil, Lee Sang Yup
Abstract excerpt
The metabolic network of Escherichia coli was constructed and was used to simulate the distribution of metabolic fluxes in wild-type E. coli and recombinant E. coli producing poly(3-hydroxybutyrate) [P(3HB)]. The flux of acetyl-CoA into the tricarboxylic acid (TCA) cycle, which competes with the P(3HB) biosynthesis pathway, decreased significantly during P(3HB) production. It was notable to find from in silico...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.