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Article

Redistribution of carbon flux toward 2,3-butanediol production in Klebsiella pneumoniae by metabolic engineering.

PloS one - 1 Jan 2014

Kim Borim, Lee Soojin, Jeong Daun, Yang Jeongmo, Oh Min-Kyu, Lee Jinwon

Abstract excerpt

Klebsiella pneumoniae KCTC2242 has high potential in the production of a high-value chemical, 2,3-butanediol (2,3-BDO). However, accumulation of metabolites such as lactate during cell growth prevent large-scale production of 2,3-BDO. Consequently, we engineered K. pneumoniae to redistribute its carbon flux toward 2,3-BDO production. The ldhA gene deletion and gene overexpression (budA and budB) were conducted to...

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Identifiers

PMID: 25329548
DOI: 10.1371/journal.pone.0105322
PMCID: PMC4203659

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