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Article

Role of transcription factor Sp1 and CpG methylation on the regulation of the human podocalyxin gene promoter

9 May 2006

Abstract excerpt

BACKGROUND: Podocalyxin (podxl) is a heavily glycosylated transmembrane protein mainly found on the apical membrane of rat podocytes and also in endothelial, hematopoietic, and tumor cells. Despite of its interest no much is known about the transcriptional regulation of podxl in different cells. Thus, we aimed at studying the functional features of the 5'-regulatory region of the human Podxl gene. RESULTS: The...

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PMID: 16684343
DOI: 10.1186/1471-2199-7-17

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