Article
Up-regulation and overproduction of DVL-1, the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma.
Oncology reports - 1 Jan 2000
Okino Keiko, Nagai Hisaki, Hatta Mitsuko, Nagahata Takemitsu, Yoneyama Koichi, Ohta Yujiro, Jin Enjing, Kawanami Oichi, Araki Tsutomu, Emi Mitsuru
Abstract excerpt
The Dvl-1 gene on chromosome 1p36 belongs to a family of highly conserved secreted proteins which regulates embryonic induction, generation of cell polarity and specification of cell fate through activation of Wnt signaling pathways. Wnt signaling activates the gene encoding DVL-1; the latter suppresses beta-catenin by promoting its degradation through enhanced inactivation of glycogen-synthase-kinase 3 (GSK3)....
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