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Article

Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin.

International journal of cancer - 15 Jan 2009

Lee Eun-Ju, Jo Minwha, Rho Seung Bae, Park Kyoungsook, Yoo Yae-Na, Park Junsoo, Chae Myounghee, Zhang Wei, Lee Je-Ho

Abstract excerpt

The Wnt/beta-catenin signaling pathway is activated during the malignant transformation of keratinocytes that originate from the human uterine cervix. Dkk1, 2 and 4 have been shown to modulate the Wnt-induced stabilization of the beta-catenin signaling pathway. However, the function of Dkk3 in this pathway is unknown. Comparison of the Dkk3 gene expression profiles in cervical cancer and normal cervical tissue by...

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Identifiers

PMID: 19003969
DOI: 10.1002/ijc.23913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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