Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene.

doi:10.2337/diabetes.47.9.1459

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Article

Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene.

Diabetes - 1 Sept 1998

Surmely J F, Guenat E, Philippe J, Dussoix P, Schneiter P, Temler E, Vaxillaire M, Froguel P, Jéquier E, Tappy L

Abstract excerpt

Mutations of the hepatocyte nuclear factor (HNF)-1alpha gene cause impaired insulin secretion and hyperglycemia in patients with maturity-onset diabetes of the young (MODY)3. Whether these mutations also affect glucose metabolism in tissues other than the beta-cell has not yet been documented. We...

Topics

Adult
Blood Glucose
DNA-Binding Proteins
Diabetes Mellitus, Type 2
Fatty Acids, Nonesterified
Female
Glucagon
Glucose
Glucose Clamp Technique
Hepatocyte Nuclear Factor 1
Hepatocyte Nuclear Factor 1-alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatocyte Nuclear Factor 1-beta

Humans

Infusions, Intravenous

Insulin

Kinetics

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 9726235
DOI: 10.2337/diabetes.47.9.1459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9726235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene.PMID 9726235Read ↗

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