Article
Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians.
Diabetes - 1 Feb 2000
Abderrahmani A, Chèvre J C, Otabe S, Chikri M, Hani E H, Vaxillaire M, Hinokio Y, Horikawa Y, Bell G I, Froguel P
Abstract excerpt
Mutations in genes encoding hepatocyte nuclear factor (HNF) are responsible for three of the five subtypes of maturity-onset diabetes of the young (MODY). This observation and molecular studies indicate that the HNF network is required for normal function of pancreatic beta-cells. This suggests that transcription factors involved in this complex network are candidates for genetic defects in MODY. Because the...
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