Article
Altered global methylation of DNA: an epigenetic difference in susceptibility for lung cancer is associated with its progression.
Human pathology - 1 Aug 2001
Piyathilake C J, Frost A R, Bell W C, Oelschlager D, Weiss H, Johanning G L, Niveleau A, Heimburger D C, Grizzle W E
Abstract excerpt
Alterations in global DNA methylation have been observed in many cancers, but whether such alterations represent an epigenetic difference in susceptibility for the disease is unknown. The status of global DNA methylation also has not been reported in intact or specific types of cells involved in the carcinogenic process. To address these issues in lung carcinogenesis, we evaluated the status of global DNA...
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