Article
Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors.
Oncogene - 17 Jul 2003
Russell John P, Shinohara Shogo, Melillo Rosa M, Castellone Maria D, Santoro Massimo, Rothstein Jay L
Abstract excerpt
Differentiated thyroid carcinomas are the most frequent endocrine neoplasms, but account for few cancer-related deaths. Although the indolent growth of these cancers correlates well with longevity, the biological basis for this good prognosis is not known. In contrast, two of the most frequent autoimmune diseases involve the thyroid suggesting a high propensity for this organ to invoke destructive immunity....
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