Article
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.
Oncotarget - 26 Jan 2016
Soares Joana, Raimundo Liliana, Pereira Nuno A L, Monteiro Ângelo, Gomes Sara, Bessa Cláudia, Pereira Clara, Queiroz Glória, Bisio Alessandra, Fernandes João, Gomes Célia, Reis Flávio, Gonçalves Jorge, Inga Alberto, Santos Maria M M, Saraiva Lucília
Abstract excerpt
Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of wild-type (wt) and mut p53, using a yeast-based screening strategy. SLMP53-1 has a p53-dependent anti-proliferative activity in human wt and mut p53R280K-expressing...
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