Article

APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

2017-11-05

Abstract excerpt

The TP 53 tumor suppressor gene is frequently inactivated in human tumors by missense mutations in the DNA binding domain. TP 53 mutations lead to protein unfolding, decreased thermostability and loss of DNA binding and transcription factor function. Pharmacological targeting of mutant p53 to restore its tumor suppressor function is a promising strategy for cancer therapy. The mutant p53 reactivating compound AP...

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Literature Corpus work: e5967091-9109-536a-87dd-00c5daf48f05
DOI: 10.1101/214049

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