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Article

Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.

Leukemia & lymphoma - 1 Mar 2015

Savorani Cecilia, Manfé Valentina, Biskup Edyta, Gniadecki Robert

Abstract excerpt

The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity and mechanism of a p53 reactivator, ellipticine, in a cellular model of cutaneous T-cell lymphoma (CTCL), a disease that is progressive, chemoresistant and refractory to treatment. We tested the effect of ellipticine...

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Source

Identifiers

PMID: 24898668
DOI: 10.3109/10428194.2014.929673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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