Article
Experience-dependent strengthening of Drosophila neuromuscular junctions.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Jul 2003
Sigrist Stephan J, Reiff Dierk F, Thiel Philippe R, Steinert Joern R, Schuster Christoph M
Abstract excerpt
The genetic analysis of larval neuromuscular junctions (NMJs) of Drosophila has provided detailed insights into molecular mechanisms that control the morphological and physiological development of these glutamatergic synapses. However, because of the chronic defects caused by mutations, a time-resolved analysis of these mechanisms and their functional relationships has been difficult so far. In this study we...
Topics
- Animals
- Cell Adhesion Molecules, Neuronal
- Drosophila
- Gene Expression Regulation
- Larva
- Male
- Motor Activity
- Mutation
- Neuromuscular Junction
- Patch-Clamp Techniques
- Physical Stimulation
- Poly(A)-Binding Proteins
- Presynaptic Terminals
- Receptors, AMPA
- Synaptic Transmission
- Temperature