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Article

Characterisation of adiponectin multimers and the IGF axis in humans with a heterozygote mutation in the tyrosine kinase domain of the insulin receptor gene.

European journal of endocrinology - 1 Mar 2012

Højlund Kurt, Beck-Nielsen Henning, Flyvbjerg Allan, Frystyk Jan

Abstract excerpt

OBJECTIVE: Low levels of adiponectin, IGF-binding protein 1 (IGFBP1) and IGFBP2 and high levels of leptin correlate with several indices of insulin resistance and risk of type 2 diabetes. However, in insulin receptoropathies, plasma adiponectin is paradoxically increased despite severe insulin resistance, whereas the IGF axis is sparsely described. Here, we aimed to characterise the multimeric distribution of...

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Share to Adiponectin
Share to Genetic Carrier Screening

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Like Growth Factor Binding Protein 1

Share to Insulin-Like Growth Factor I

Share to Insulin-Like Growth Factor II

Share to Protein Multimerization

Share to Protein-Tyrosine Kinases

Share to Receptor, Insulin

Source

Identifiers

PMID: 22189999
DOI: 10.1530/EJE-11-0790

Genes

IGF1
IGFBP1
IGFBP2
IGF2
INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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