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Article

A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin.

The FEBS journal - 1 Jul 2012

Radjainia Mazdak, Huang Bosheng, Bai Bo, Schmitz Michael, Yang Sung H, Harris Paul W R, Griffin Michael D W, Brimble Margaret A, Wang Yu, Mitra Alok K

Abstract excerpt

Adiponectin is a collagenous adipokine with direct anti-diabetic and anti-atherogenic properties. It can assume an ensemble of oligomeric states, e.g. trimers, hexamers and octadecamers, each being involved in distinct signaling pathways relevant to adiponectin's diverse biological function in metabolism, immunity, inflammation and cellular homeostasis. Assembly of the active variants principally the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22583869
DOI: 10.1111/j.1742-4658.2012.08630.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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