Article
Endoplasmic reticulum (ER) localization is critical for DsbA-L protein to suppress ER stress and adiponectin down-regulation in adipocytes.
The Journal of biological chemistry - 17 Apr 2015
Liu Meilian, Chen Hongzhi, Wei Li, Hu Derong, Dong Kun, Jia Weiping, Dong Lily Q, Liu Feng
Abstract excerpt
Adiponectin is an adipokine with insulin-sensitizing and anti-inflammatory functions. We previously reported that adiponectin multimerization and stability are promoted by the disulfide bond A oxidoreductase-like protein (DsbA-L) in cells and in vivo. However, the precise mechanism by which DsbA-L regulates adiponectin biosynthesis remains elusive. Here we show that DsbA-L is co-localized with the endoplasmic...
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