Article
Independence of growth factor induced plasminogen activator inhibitor type-1 (PAI-1) expression from the 4G/5G polymorphism of the PAI-1 gene.
Thrombosis and haemostasis - 1 Jul 2003
Nordt Thomas K, Eschenfelder Esther, Peter Karlheinz, Sobel Burton E, Bode Christoph
Abstract excerpt
Increased PAI-1 expression has been implicated in accelerating atherogenesis. Increases under some conditions are modulated by growth factors. Genetic factors such as the 4G/5G polymorphism in the promoter of the PAI-1 gene play a role under certain circumstances. The present study was designed to delineate for the first time interactions between growth factors and the 4G/5G polymorphism with respect to PAI-1...
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