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Article

Role of tryptophan 121 in the soluble CuA domain of cytochrome c oxidase: structure and electron transfer studies.

Protein engineering - 1 Jun 2003

Song Ai-Xin, Li Lian-Zhi, Yu Ting, Chen Shi-Ming, Huang Zhong-Xian

Abstract excerpt

To investigate the contribution of tryptophan-121 (Trp121) residue to the structure and function of soluble CuA domain of cytochrome c oxidase, three mutant proteins, Trp121Tyr, Trp121Leu and Trp121-deleted mutant of the soluble domain of Paracoccus versutus cytochrome c oxidase, were constructed and expressed in Escherichia coli BL21 (DE3). Optical spectral studies showed that both the coordination structure of...

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PMID: 12874377
DOI: 10.1093/protein/gzg059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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