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Article

Delineation of the Molecular Mechanisms ofFrancisella tularensis-Induced Apoptosis in Murine Macrophages

21 Jul 2003

Abstract excerpt

Francisella tularensis is a facultative intracellular bacterium capable of inducing apoptosis in murine macrophages. Here we analyzed the pathway leading to apoptosis in the murine macrophage-like cell line J774A.1 after infection with F. tularensis strain LVS (named LVS for live vaccine strain). We obtained evidence that the infection affected the mitochondria of the macrophages, since it induced release of the...

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PMID: 12874344
DOI: 10.1128/iai.71.8.4642-4646.2003

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