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Article

The human ARHI tumor suppressor gene inhibits lactation and growth in transgenic mice.

Cancer research - 1 Sept 2000

Xu F, Xia W, Luo R Z, Peng H, Zhao S, Dai J, Long Y, Zou L, Le W, Liu J, Parlow A F, Hung M C, Bast R C, Yu Y

Abstract excerpt

ARHI is a novel imprinted tumor suppressor gene. To study its function in vivo, we have developed transgenic mice that overexpress ARHI. Offspring bearing the transgene had significantly lower body weights than did nontransgenic littermates. In addition, strong expression of the ARHI transgene was associated with greatly impaired mammary gland development and lactation, failure of ovarian folliculogenesis...

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Share to Growth Hormone
Share to Growth Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mice, Inbred ICR

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Source

Identifiers

PMID: 10987306

Genes

PRL

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