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Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation.

Human molecular genetics - 1 Aug 2003

Fujii Satoshi, Luo Robert Z, Yuan Jiuhong, Kadota Mitsutaka, Oshimura Mitsuo, Dent Sharon R, Kondo Yutaka, Issa Jean-Pierre J, Bast Robert C, Yu Yinhua

Abstract excerpt

ARHI has been identified as a maternally imprinted tumor suppressor gene that maps to chromosome 1p31 and whose expression is markedly down-regulated in breast cancer. To explore possible mechanisms that could silence ARHI expression, we have tested the importance of DNA methylation, histone acetylation and histone methylation in regulating ARHI expression. We found that treatment with CpG demethylating agents...

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PMID: 12874100
DOI: 10.1093/hmg/ddg204

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Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation.PMID 12874100Read ↗

Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.Semantic proximity Read ↗

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