Article
Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study.
Mutation research - 25 Jul 2003
Zheng Siqun L, Mychaleckyj Josyf C, Hawkins Gregory A, Isaacs Sarah D, Wiley Kathy E, Turner Aubrey, Chang Bao-li, von Kap-Herr Chris, Carpten John D, Pettenati Mark, Bleecker Eugene R, Walsh Patrick C, Trent Jeffrey M, Meyers Deborah A, Isaacs William B, Xu Jianfeng
Abstract excerpt
A gene or genes on chromosome 8p22-23 have been implicated in prostate carcinogenesis by the observation of frequent deletions of this region in prostate cancer cells. More recently, two genetic linkage studies in hereditary prostate cancer (HPC) families suggest that germline variation in a gene in this region may influence prostate cancer susceptibility as well. DLC1 (deleted in liver cancer), a gene in this...
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