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Article

Structure-Activity Relationships of HIV-1 Integrase Inhibitors - Enzyme- Ligand Interactions

1 Sept 2003

Abstract excerpt

HIV-1 integrase is an essential enzyme for retroviral replication. It is involved in the integration of HIV DNA into host chromosomal DNA and appears to have no functional equivalent in human cells. Therefore it is an attractive and rational target for selective anti-AIDS therapy. A great number of HIV-1 integrase inhibitors have been described in the last decade and numerous reviews have been published. The...

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PMID: 12871105
DOI: 10.2174/0929867033456981

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