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Recent Advances in Small-Molecule HIV-1 Integrase Inhibitors

18 Jan 2021

Abstract excerpt

HIV-1 integrase catalyzed the insertion of viral DNA into the genome of human cells in the process of retrotranscription. Integrase is an attractive target for HIV-1 treatment due to the lack of its homologue in human cells and its vital role in HIV-1 replication. Although major progress in the development of HIV-1 integrase inhibitors has been made, some thorny problems, such as drug resistance, led to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33459224
DOI: 10.2174/0929867328666210114124744

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