Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

doi:10.1074/jbc.M303621200

Article

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.

The Journal of biological chemistry - 10 Oct 2003

Lu Yiling, Yu Qinghua, Liu Jue Hui, Zhang Jinyi, Wang Hongwei, Koul Dimpy, McMurray John S, Fang Xianjun, Yung W K Alfred, Siminovitch Kathy A, Mills Gordon B

Abstract excerpt

Src family protein-tyrosine kinases, which play an important role in signal integration, have been implicated in tumorigenesis in multiple lineages, including breast cancer. We demonstrate, herein, that Src kinases regulate the phosphatidylinositol 3-kinase (PI3K) signaling cascade via altering the function of the PTEN tumor suppressor. Overexpression of activated Src protein-tyrosine kinases in PTEN-deficient...

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