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Article

Cytoplasmically retargeted HSV1-tk/GFP reporter gene mutants for optimization of noninvasive molecular-genetic imaging.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Ponomarev Vladimir, Doubrovin Michael, Serganova Inna, Beresten Tatiana, Vider Jelena, Shavrin Aleksander, Ageyeva Ludmila, Balatoni Julius, Blasberg Ronald, Tjuvajev Juri Gelovani

Abstract excerpt

To optimize the sensitivity of imaging HSV1-tk/GFP reporter gene expression, a series of HSV1-tk/GFP mutants was developed with altered nuclear localization and better cellular enzymatic activity, compared to that of the native HSV1-tk/GFP fusion protein (HSV1-tk/GFP). Several modifications of HS...

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PMID: 12869307
DOI: 10.1016/S1476-5586(03)80056-8
PMCID: PMC1502405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12869307-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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