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Article

Generation of destabilized herpes simplex virus type 1 thymidine kinase as transcription reporter for PET reporter systems in molecular genetic imaging.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Jan 2008

Hsieh Chia-Hung, Chen Fu-Du, Wang Hsin-Ell, Hwang Jeng-Jong, Chang Chi-Wei, Lee Yi-Jang, Gelovani Juri G, Liu Ren-Shyan

Abstract excerpt

UNLABELLED: Herpes simplex virus type 1 thymidine kinase (HSV1-TK) is a widely used reporter for in vivo noninvasive monitoring of therapeutic gene expression, immune cell trafficking, and protein-protein interactions in various animal systems. However, the stability of HSV1-TK limits its application in studies that require rapid turnover of the reporter. The purpose of this study was to create a destabilized...

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Identifiers

PMID: 18077523
DOI: 10.2967/jnumed.106.038943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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