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Article

Characterization of multiple nuclear localization signals in herpes simplex virus type 1 thymidine kinase.

Biochemical and biophysical research communications - 22 Oct 1999

Degrève B, Esnouf R, De Clercq E, Balzarini J

Abstract excerpt

We have reported previously that the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) fused with green fluorescent protein (GFP) is localized in the nucleus of HSV-1 TK-GFP gene-transfected cells (Degrève et al. (1998) J. Virol. 72, 9535-9543). Deletion of the N-terminal 34 amino acids or selective mutation of the nonapeptide (25)RRTALRPRR(33), located in the N-terminal region of HSV-1 TK, resulted in...

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PMID: 10529365
DOI: 10.1006/bbrc.1999.1485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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