Article
Association of keratin 8 gene mutation with chronic pancreatitis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jun 2003
Cavestro G M, Frulloni L, Nouvenne A, Neri T M, Calore B, Ferri B, Bovo P, Okolicsanyi L, Di Mario F, Cavallini G
Abstract excerpt
BACKGROUND: Keratin 8 (K8) and 18 (K18) are the major components of the intermediate filament cytoskeleton of pancreatic acinar cells and play a relevant role in pancreatic exocrine homeostasis. Transgenic mice for K8 have shown to display progressive exocrine pancreas alterations, including dysplasia, loss of acinar architecture, redifferentiation of acinar to ductal cells, inflammation, fibrosis, and...
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