Article
CFTR polymorphisms in patients with alcoholic chronic pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2009
da Costa Marianges Zadrozny Gouvêa, Guarita Dulce Reis, Ono-Nita Suzane Kioko, Nogueira Jerônimo de Alencar, Nita Marcelo Eidi, Paranaguá-Vezozzo Denise Cerqueira, de Souza Marcelo Tavares, do Carmo Eliane Pereira, Teixeira Ana Cristina de Sá, Carrilho Flair José
Abstract excerpt
INTRODUCTION: Pancreas susceptibility to alcohol is variable and only 5-10% of chronic alcohol abusers develop chronic pancreatitis; the role of genetic factors in this process is unknown. The CFTR gene encodes a protein that acts on epithelial cells and plays a key role in normal exocrine pancreatic function. METHODS: This study investigated the frequency of polymorphisms in intron 8 of the CFTR gene in patients...
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