Article
Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement.
Neurobiology of aging - 1 Jan 2000
Nicoll James A R, Yamada Masahito, Frackowiak Janusz, Mazur-Kolecka Bozena, Weller Roy O
Abstract excerpt
For the purposes of this debate here we argue the case that cerebral amyloid angiopathy (CAA) has a direct role in the pathogenesis of Alzheimer's disease (AD). Firstly, there is a very close relationship between CAA and AD and they share genetic risk factors. Secondly, we propose a specific mechanism which puts age-related cerebrovascular degeneration at a crucial point in the pathogenesis of AD as follows....
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