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Article

Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

British journal of cancer - 21 Jul 2003

Lim W, Hearle N, Shah B, Murday V, Hodgson S V, Lucassen A, Eccles D, Talbot I, Neale K, Lim A G, O'Donohue J, Donaldson A, Macdonald R C, Young I D, Robinson M H, Lee P W R, Stoodley B J, Tomlinson I, Alderson D, Holbrook A G, Vyas S, Swarbrick E T, Lewis A A M, Phillips R K S, Houlston R S

Abstract excerpt

Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz-Jeghers syndrome (PJS), a rare dominant disorder. In addition to typical hamartomatous gastrointestinal polyps and pigmented perioral lesions, PJS is associated with an increased risk of tumours at multiple sites. Follow-up information on carriers is limited and genetic heterogeneity makes counselling and management in PJS difficult. Here we...

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Source

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Identifiers

PMID: 12865922
DOI: 10.1038/sj.bjc.6601030
PMCID: PMC2394252

Genes

STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.PMID 12865922Read ↗

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Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study.Semantic proximity Read ↗

Molecular and clinical characteristics in 46 families affected with Peutz-Jeghers syndrome.Semantic proximity Read ↗

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The molecular basis and clinical aspects of Peutz-Jeghers syndrome.Semantic proximity Read ↗

STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients.Semantic proximity Read ↗

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