Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study.

doi:10.1016/j.dld.2012.12.018

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Article

Cancer risk associated with STK11/LKB1 germline mutations in Peutz-Jeghers syndrome patients: results of an Italian multicenter study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jul 2013

Resta Nicoletta, Pierannunzio Daniela, Lenato Gennaro Mariano, Stella Alessandro, Capocaccia Riccardo, Bagnulo Rosanna, Lastella Patrizia, Susca Francesco Claudio, Bozzao Cristina, Loconte Daria Carmela, Sabbà Carlo, Urso Emanuele, Sala Paola, Fornasarig Mara, Grammatico Paola, Piepoli Ada, Host Cristina, Turchetti Daniela, Viel Alessandra, Memo Luigi, Giunti Laura, Stigliano Vittoria, Varesco Liliana, Bertario Lucio, Genuardi Maurizio, Lucci Cordisco Emanuela, Tibiletti Maria Grazia, Di Gregorio Carmela, Andriulli Angelo, Ponz de Leon Maurizio

Abstract excerpt

BACKGROUND: Germline mutations in the STK11/LKB1 gene cause Peutz-Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of the first Italian collaborative study on Peutz-Jeghers syndrome. AIMS: To assess cancer risks in a large homogenous cohort...

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PMID: 23415580
DOI: 10.1016/j.dld.2012.12.018

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STK11

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