Article
Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000
Goodarzi Mark O, Guo Xiuqing, Taylor Kent D, Quiñones Manuel J, Samayoa Carlos, Yang Huiying, Saad Mohammad F, Palotie Aarno, Krauss Ronald M, Hsueh Willa A, Rotter Jerome I
Abstract excerpt
PURPOSE: To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease. METHODS: Six polymorphisms sufficient to distinguish the most common haplotypes in the 3' end of LPL were identified by genotyping 10 polymorphisms in a small pilot population. These were used to haplotype LPL in large family samples of Mexican-Americans...
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